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KMID : 0882420100780010132
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Korean Journal of Medicine
2010 Volume.78 No. 1 p.132 ~ p.137
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Complete remission of philadelphia chromosome-positive acute myeloid leukemia with imatinib mesylate
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Jang Saet-Byul
Ryoo Hun-Mo
Bae Sung-Hwa
Jeun Eon-Ju
Kang Gun-Woo
Jung Hye-Ryun
Yoon So-Yeon
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Abstract
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Philadelphia chromosome-positive acute myeloid leukemia (Ph+AML) is a rare disease characterized by a poor prognosis with resistance to standard chemotherapy. We report a patient with Ph+AML with a minor BCR-ABL-positive mRNA transcript who achieved a hematologic, cytogenetic, and major molecular complete response after cytarabine-based chemotherapy followed by imatinib. After more than 6 months of continuous imatinib therapy, the patient is in continuous complete remission. Our results show that imatinib mesylate is effective in treating Ph+AML. (Korean J Med 78:132-137, 2010)
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KEYWORD
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Leukemia, Myeloid, Acute, Philadelphia chromosome, Imatinib mesylate
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